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@bigbio

BigBio Stack

Provide big data solutions Bioinformatics

Welcome to bigbio 👋

bigbio is an open-source organization dedicated to advancing bioinformatics and computational proteomics and multiomics research. We develop scalable tools, workflows, and libraries to support complex experimental designs in proteomics, genomics and multiomics. Our mission is to empower researchers with accessible, efficient, and cutting-edge solutions for data analysis and integration.

🌟 Key Projects

🔬 Proteomics and Quantitative Analysis

  • quantms: A comprehensive workflow for proteomics experiments supporting DDA-LFQ, DDA-Isobaric, and DIA-LFQ quantification.
  • qpx: A proteomics quantification format extending mzTab for large-scale datasets.
  • ibaqpy: A package for absolute quantification based on the quantms.io format.
  • quantms.org: Code for quantms.org, a resource for reanalysis and public proteomics data.

🧪 Multiomics and Metadata Tools

⚡ Workflow Utilities

  • pmultiqc: A QC report library based on the MultiQC framework.
  • spectrafuse: An incremental clustering pipeline for quantms data.
  • quantms-utils: Helper scripts and classes for the quantms workflow.
  • quantms-rescoring: Helper functions and scripts for quantms and ms2rescore.

🤝 Contributions

We welcome contributions from the community! Whether it's bug fixes, feature suggestions, or documentation improvements, every contribution helps drive bioinformatics research forward.

🔗 Stay Connected

Join us on this journey to revolutionize data analysis in proteomics and beyond!

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  1. proteomics-sample-metadata proteomics-sample-metadata Public

    SDRF: The Proteomics sample metadata: Standard for experimental design annotation in proteomics datasets

    HTML 116 116

  2. quantms quantms Public

    Quantitative mass spectrometry workflow. Currently supports proteomics experiments with complex experimental designs for DDA-LFQ, DDA-Isobaric and DIA-LFQ quantification.

    Nextflow 83 57

Repositories

Showing 10 of 60 repositories
  • quantmsdiann Public

    quantms workflow for DIANN tool including DIA and DDA analysis

    bigbio/quantmsdiann's past year of commit activity
    Nextflow 19 MIT 36 1 2 Updated Sep 22, 2026
  • sdrf-annotated-datasets Public

    A repository of datasets in ProteomeXchange annotated in SDRF, previously part of the specification

    bigbio/sdrf-annotated-datasets's past year of commit activity
    Python 12 Apache-2.0 28 0 1 Updated Sep 22, 2026
  • pmultiqc Public

    A library for QC report based on MultiQC framework

    Python 34 MIT 29 12 2 Updated Sep 22, 2026
  • hvantk Public

    Hail variant annotation toolkit

    bigbio/hvantk's past year of commit activity
    Python 1 MIT 0 24 2 Updated Sep 22, 2026
  • proteomics-sample-metadata Public

    SDRF: The Proteomics sample metadata: Standard for experimental design annotation in proteomics datasets

    bigbio/proteomics-sample-metadata's past year of commit activity
    HTML 116 GPL-2.0 116 26 (3 issues need help) 0 Updated Sep 22, 2026
  • sdrf-skills Public

    Agentic plugins to annotate SDRF using Claude; Codex; Cursor; Gemini

    bigbio/sdrf-skills's past year of commit activity
    Python 18 MIT 12 0 0 Updated Sep 21, 2026
  • sdrf-pipelines Public

    SDRF official validator and converts SDRF to pipeline configuration files

    bigbio/sdrf-pipelines's past year of commit activity
    Python 37 Apache-2.0 33 15 0 Updated Sep 21, 2026
  • qpx Public

    qpx (Quantitative Proteomics eXchange) format (aka quantms.io) a format to capture a full proteomics experiment

    bigbio/qpx's past year of commit activity
    Python 26 Apache-2.0 8 11 0 Updated Sep 17, 2026
  • quantms-portal Public

    Tooling and frontend for portal.quantms.org — AI-first proteomics data portal

    bigbio/quantms-portal's past year of commit activity
    Vue 1 2 4 0 Updated Sep 17, 2026
  • quantms.org Public

    Web page storing all the datasets renalyzed with quantms

    bigbio/quantms.org's past year of commit activity
    HTML 0 MIT 5 0 0 Updated Sep 17, 2026

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