Issues

• Peroxisomal β-oxidation GPRs join alternative enzymes with "and" and list mitochondrial enzymes (98 reactions)

  SysBioChalmers/Human-GEM#1159 · Filter by author edkerk opened on Oct 8, 2026
  1

• Free trimethyllysine release (MAR06978, MAR08029) is assigned to the signal peptidase complex

  SysBioChalmers/Human-GEM#1157 · Filter by author edkerk opened on Oct 8, 2026

• MMAA is the GPR of cobalamin transport and adenosyltransferase reactions (MAR08614-MAR08616), but it is the chaperone of MMUT

  SysBioChalmers/Human-GEM#1156 · Filter by author edkerk opened on Oct 8, 2026
  1

• DNA methyltransferase GPR (MAR04072, MAR08640, MAR08641) lists TRDMT1 and DNMT3L, and makes DNMT1 need DNMT3B

  SysBioChalmers/Human-GEM#1155 · Filter by author edkerk opened on Oct 8, 2026

• Mass and charge imbalances, and structures that disagree with formula or charge

  SysBioChalmers/Human-GEM#1153 · Filter by author edkerk opened on Oct 8, 2026
  1

• Essential tasks allow no proton exchange, so 28 of them pass only through charge-unbalanced reactions

  SysBioChalmers/Human-GEM#1152 · Filter by author edkerk opened on Oct 8, 2026
  1

• Twelve reactions convert fatty acids between the n-3 and n-6 series, so the model makes arachidonate without linoleate and DHA without linolenate

  SysBioChalmers/Human-GEM#1151 · Filter by author edkerk opened on Oct 8, 2026
  1

• The CoQ head group is made through a plant 4-coumarate route instead of HPDL

  SysBioChalmers/Human-GEM#1150 · Filter by author edkerk opened on Oct 7, 2026
  1

• Six gene-free reactions that growth needs have known human enzymes (PEDS1, COQ4, PRUNE1, FADS2, MTRR, LRAT)

  SysBioChalmers/Human-GEM#1149 · Filter by author edkerk opened on Oct 7, 2026
  1

• Urate oxidase (MAR06611) has no GPR, so every human cell can oxidise urate to allantoin

  SysBioChalmers/Human-GEM#1147 · Filter by author edkerk opened on Oct 7, 2026
  1

• Heteromeric amino acid transporters: SLC7 light chains lack their SLC3 heavy chain in 423 GPRs, and the b0,+ rule includes SLC7A6

  bugwip
  SysBioChalmers/Human-GEM#1142 · Filter by author chechung opened on Oct 6, 2026
  2

• Steroid hormone synthesis: CYP17A1 lyase copies, the HSD3B isomerase, cortisol side-chain cleavage and 11-oxygenated androgens

  SysBioChalmers/Human-GEM#1134 · Filter by author edkerk opened on Oct 2, 2026

• Curate dead-end pathways

  SysBioChalmers/Human-GEM#1133 · Filter by author edkerk opened on Oct 2, 2026

• Peroxisomal β-oxidation and carnitine exchange

  SysBioChalmers/Human-GEM#1131 · Filter by author edkerk opened on Sep 30, 2026 · 2.2.0

• Mitochondrial β-oxidation: electron acceptors and GPRs

  SysBioChalmers/Human-GEM#1130 · Filter by author edkerk opened on Sep 30, 2026 · 2.2.0
  2

• Mitochondrial β-oxidation: one reaction per step, no lumped or duplicate reactions

  SysBioChalmers/Human-GEM#1129 · Filter by author edkerk opened on Sep 30, 2026 · 2.2.0

• Leukotriene and oxidised fatty-acid catabolism

  SysBioChalmers/Human-GEM#1128 · Filter by author edkerk opened on Sep 30, 2026 · 2.2.0
  1

• Fatty-acid oxidation: merge duplicate acyl-CoA and fatty-acid metabolites

  SysBioChalmers/Human-GEM#1127 · Filter by author edkerk opened on Sep 30, 2026 · 2.2.0

• Wrong GPRs on the DHAP route to lysophosphatidic acid and ether lipids make GNPAT and AKR1A1 falsely essential

  SysBioChalmers/Human-GEM#1120 · Filter by author edkerk opened on Sep 28, 2026 · 2.2.0
  1

• Ceramidase reactions are in the cytosol, where no ceramidase acts

  SysBioChalmers/Human-GEM#1119 · Filter by author edkerk opened on Sep 28, 2026 · 2.2.0

• Redefine the biomass reactions MAR13082 and MAR00021 (and review the tasks that depend on them)

  SysBioChalmers/Human-GEM#1118 · Filter by author edkerk opened on Sep 28, 2026 · 2.2.0
  3

• Cholesterol synthesis exists twice (cytosol and ER): reconcile into one pathway

  SysBioChalmers/Human-GEM#1117 · Filter by author edkerk opened on Sep 27, 2026 · 2.2.0

• Mitochondrial fatty-acid synthesis is in the cytosol, so lipoic acid synthesis is disconnected

  SysBioChalmers/Human-GEM#1102 · Filter by author edkerk opened on Sep 25, 2026 · 2.2.0
  1

• Curate reaction reversibility, starting with thermodynamically irreversible reactions

  fixed in develop
  SysBioChalmers/Human-GEM#1083 · Filter by author edkerk opened on Sep 24, 2026 · 2.2.0
  3

• Evaluate and curate GPR-less transport reactions

  SysBioChalmers/Human-GEM#1071 · Filter by author edkerk opened on Jul 21, 2026 · 2.2.0
  2