Issues

• [Model] Discussion : work on PKPD model integration

  enhancement
  Feature

  LAPKB/PMcore#331 · Filter by author R-garreau opened on Oct 2, 2026
  10

• Interest in trying Basin for BestDose optimization?

  LAPKB/PMcore#322 · Filter by author jolars opened on Sep 7, 2026
  2

• [Bestdose] Nelder-Mead starting point optimization

  enhancementquestion
  LAPKB/PMcore#321 · Filter by author R-garreau opened on Sep 7, 2026
  4

• [bestdose] covariates are not carried when optimizing AUC

  Bug

  LAPKB/PMcore#315 · Filter by author R-garreau opened on Aug 21, 2026
  4

• BestDose : posterior probability issue

  bug
  LAPKB/PMcore#312 · Filter by author R-garreau opened on Aug 14, 2026
  5

• Chaining should use the optimized value of gamma/lambda

  improvements
  Task

  LAPKB/PMcore#293 · Filter by author mhovd opened on Jul 1, 2026
  

• BestDose : switch AUC calculation to log-linear trapezoidal

  enhancement
  Feature

  LAPKB/PMcore#275 · Filter by author R-garreau opened on Apr 24, 2026
  2

• BestDose: bias_weight

  LAPKB/PMcore#249 · Filter by author mnneely opened on Mar 13, 2026

• Add calculation of the D-optimality criterion to the algorithm trait

  LAPKB/PMcore#238 · Filter by author mhovd opened on Dec 14, 2025

• BestDose requests

  Feature

  LAPKB/PMcore#221 · Filter by author mhovd opened on Nov 7, 2025
  7

• Consider alternative distribution functions for the likelihood

  enhancement
  Feature

  LAPKB/PMcore#128 · Filter by author mhovd opened on May 7, 2025

• Support outputs as Poisson

  Feature

  LAPKB/PMcore#121 · Filter by author mhovd opened on Apr 23, 2025

• Add global variables to model

  enhancementmissing functionality
  LAPKB/PMcore#26 · Filter by author mhovd opened on Nov 24, 2023